Current and future treatments for cognitive deficits in dementia |
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Authors: | Beth M McLendon PharmD Gerome G Chen BS P Murali Doraiswamy MD |
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Institution: | (1) Duke University Medical Center, Box 3018, 27710 Durham, NC, USA |
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Abstract: | In this article, we primarily focus on the treatment approaches currently marketed and in advanced stages of development for
Alzheimer’s disease (AD). Amyloid plaques and neurofibrillary tangles remain the pathologic hallmarks of AD, and much progress
has been made in unraveling the molecular biology of these changes. In addition, there is also intense research into inflammatory
and oxidative mechanisms as well as vascular and neurochemical alterations in AD. Therapies targeted at these mechanisms are
discussed. |
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Keywords: | |
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