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Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease |
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| Authors: | E. Zonneveld‐Huijssoon S. Albani B. J. Prakken F. van Wijk |
| Affiliation: | 1. Department of Pediatric Immunology, Centre for Cellular and Molecular Intervention, University Medical Centre Utrecht, Utrecht, the Netherlands;2. EUREKA Institute for Translational Medicine, Siracusa, Italy;3. Sanford‐Burnham Medical Research Institute, Translational Research Laboratory, Inflammatory and Infectious Disease Center, La Jolla, CA, USA |
| Abstract: | Mucosal administration of an antigen eliciting bystander suppression at the site of inflammation results in effective antigen‐specific immunotherapy for autoimmune diseases. Heat shock proteins are bystander antigens that are effective in peptide‐specific immunotherapy in both experimental and human autoimmune disease. The efficacy of preventive peptide immunotherapy is increased by enhancing peptide‐specific immune responses with proinflammatory agents. Combining peptide‐specific immunotherapy with general suppression of inflammation may improve its therapeutic effect. |
| Keywords: | arthritis heat shock protein mucosal peptide therapy |