Inhibition of drug-metabolizing enzymes in the mouse after treatment with host-mediating antitumor drugs |
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| Authors: | Hojo Hiroshi Hashimoto Yoshiyuki |
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| Institution: | Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980 Japan |
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| Abstract: | The effect of host-mediating antitumor drugs on drug-metabolizing enzymes and cytochrome P-450 of the mouse liver was studied. Treatment of mice with a streptococcal preparation (OK-432), Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS), or protein-bound polysaccharide (PSK) depressed aniline hydroxylase and aminopyrine N-demethylase activities in a dose-responding fashion. Cytochrome P-450 content of the hepatic microsomes was also decreased by the treatment. Time of sleeping induced by pentobarbital was prolonged by the drug treatment. |
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| Keywords: | BCG Bacillus Calmette-Guérin CWS cell-wall skelton PSK protein-bound polysaccharide |
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