Pustular‐type drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to carbamazepine with systemic muscle involvement |
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Authors: | Haruna Matsuda Kanami Saito Yoshikazu Takayanagi Toshio Okazaki Kenji Kashima Kazushi Ishikawa Yoshitaka Kai Naoko Takeo Yutaka Hatano Osamu Okamoto Sakuhei Fujiwara |
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Institution: | 1. Department of Dermatology, Faculty of Medicine, Oita University, , Yufu City, Japan;2. Department of Neurology, Faculty of Medicine, Oita University, , Yufu City, Japan;3. Department of Diagnositic Pathology, Faculty of Medicine, Oita University, , Yufu City, Japan |
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Abstract: | Drug‐induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe reaction usually associated with maculopapular eruptions and systemic involvement. Here we report the first case, to our knowledge, of DIHS/DRESS due to carbamazepine with acute generalized pustular bacterid‐like (AGPB‐like) eruptions and skeletal muscle involvement. Reviewing our case and the published work, we discuss pustular‐type DIHS/DRESS which, in most cases, involves acute generalized exanthematous pustulosis (AGEP)‐like skin eruptions in response to carbamazepine. Pustular eruptions may appear in relatively few cases of DIHS/DRESS, in particular, when the causative drug is carbamazepine and, even in cases of intractable pustular bacterid‐like eruptions, a reaction to a drug should be suspected. Skeletal muscle involvement may be associated with DIHS/DRESS as one of its systemic manifestations. |
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Keywords: | acute generalized exanthematous pustulosis acute generalized pustular bacterid carbamazepine drug‐induced hypersensitivity syndrome human herpesvirus 6 skeletal muscle |
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