Assessing exposure,uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments |
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| Authors: | Birgit?K?Gaiser Teresa?F?Fernandes Mark?Jepson Jamie?R?Lead Charles?R?Tyler Vicki?Stone |
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| Affiliation: | 1.Edinburgh Napier University, Merchiston Campus,Edinburgh,UK;2.Cell Imaging Facility and Department of Biochemistry,University of Bristol,Bristol,UK;3.School of Geography, Earth and Environmental Science,University of Birmingham,Edgbaston,UK;4.Environmental and Molecular Fish Biology, The Hatherly Laboratories,University of Exeter,Exeter,UK |
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| Abstract: | The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and CeO2 particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano CeO2 = micro CeO2. Such consistency suggests that further studies might allow extrapolation of results between different models and species. |
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