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| 中国农村地区全身强直-阵挛发作癫癎患者的认知功能评估 | |
| 引用本文： | 张庆,丁玎,林卫红,周东,吴庆生,杨希晨,王文志,吴建中,洪震.中国农村地区全身强直-阵挛发作癫癎患者的认知功能评估[J].中国临床神经科学,2010,18(4):343-348. |
| 作者姓名： | 张庆 丁玎 林卫红 周东 吴庆生 杨希晨 王文志 吴建中 洪震 |
| 作者单位： | 1. 宁夏医学院附属医院神经内科,750004;复旦大学附属华山医院神经病学研究所,200040 2. 复旦大学附属华山医院神经病学研究所,200040 3. 吉林大学第一医院神经内科,130021 4. 华西医院神经内科,610041 5. 安徽省疾病预防控制中心,230001 6. 河北省沧州疾病预防控制中心,061000 7. 北京市神经外科研究所,100050 |
| 摘 要： | 目的：评价中国农村地区未经抗癫癎药物（AEDs）治疗的全身强直-阵挛发作（GTCS）癫癎患者的认知功能的状况.方法：采用数字广度测验、言语流畅性测验、听觉词语测验及数字划消测验对144例GTCS患者和144名健康对照者进行认知功能评定.结果：GTCS患者的注意力及计算能力较差,并有瞬间语言记忆、自发的语言运动能力、思维组织能力及干扰抑制能力的下降.结论：未经AEDs治疗的GTCS患者存在广泛的认知功能障碍.AEDs的非规范使用是认知功能损害的主要影响因素. |
| 关 键 词： | 全身强直－阵挛发作 癫癎 认知功能 神经心理学 |
Evaluation of Cognitive Function in Untreated Patients with Generalized Tonic-clonic Seizure in Rural China |
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| ZHANG Qing,DING Ding,LIN Wei-Hong,ZHOU Dong,WU Qing-Sheng,YANG Xi-Chen,WANG Wen-Zhi,WU Jian-Zhong,HONG Zhen.Evaluation of Cognitive Function in Untreated Patients with Generalized Tonic-clonic Seizure in Rural China[J].Chinese Journal of Clinical Neurosciences,2010,18(4):343-348. | |
| Authors: | ZHANG Qing DING Ding LIN Wei-Hong ZHOU Dong WU Qing-Sheng YANG Xi-Chen WANG Wen-Zhi WU Jian-Zhong HONG Zhen |
| Institution: | 1 Department of Neurology, Ningxia Medical University Affiliated Hospital 750004; 2Institute of Neurology, Huashan Hospital, Fudan University 200040; 3Department of Neurology, Jilin University Affiliated No. 1 Hospital 130021; 4Department of Neurology, Huaxi Hospital 610041; 5Center of Disease Prevention and Control, Anhui Province 230001; 6Center of Disease Prevention and Control, Changzhou, Hebei Province, Changzhou 061000; 7Beijing Institute of Neurosurgery, Beijing 100050, China) |
| Abstract: | Aim： To evaluate the cognitive function in untreated patients with generalized tonic-clonic seizure （GTCS）. Methods： 144 patients with GTCS and 144 normal controls were evaluated with a battery of neuropsychologic tests, which comprises Digit Span Test, Verbal Fluency Test, Auditory Verbal Learning Test and Digit Cancellation Test. Results： Patients with GTCS performed worse of general cognitive deficits, such as verbal memory, episodic memory, verbal learning capacity, visual spatial memory, attention, and calculative ability. Conclusion： The cognitive function of untreated patients with GTCS are widely impaired. Unstandardized treatment with anti-epileptic drug is the main impact factor of cognitive function impairment. |
| Keywords: | generalized tonic-clonic seizure epilepsy cognitive function neuropsychology |
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