糖尿病患者焦虑抑郁情绪的药物干预

目的探讨抗焦虑抑郁药物对糖尿病患者糖代谢的影响及临床意义。方法采用Zung抑郁自评量表(SDS)与Zung焦虑自评量表(SAS)选择糖尿病伴抑郁焦虑症状患者90例。随机分为A组(黛力新组),B组(多虑平组)及C组(对照组),每组30例。经8周治疗后测治疗前后三组患者的SDS、SAS评分及空腹血糖、餐后2h血糖、糖化血红蛋白并评价药物不良反应。结果治疗8周后A组(黛力新组)及B组(多虑平组)的SDS、SAS评分明显降低(P<0.01),三组FPG、2hPG、HbAlc均有明显下降(P<0.01,P<0.05),但A组和B组较C组下降更明显(P<0.05)。A组药物不良反应明显较B组少(P<0.01)。结论抗焦虑抑郁药物能明显改善糖尿病患者的焦虑及抑郁症状,并有助于患者的血糖控制。

Clinical Value of Drug Interference in Diabetes Patients with Anxious and Depressive Mood

Objective To study the clinical value of the effect of antianxiety and antidepression drugs on glucose metabolism of patients with diabetes mellitus.Methods 90 diabetes patients accompanied with symptoms of anxiety and depression were chosen by means of Zung's Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS).These patients were equally randomly divided into three groups: group A (Deanxiet),group B (Adapin ) and group C (control).Standard scores of SDS and SAS were evaluated with SDS and SAS, fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG) and HbA1c were measured before and after 8 weeks trial.Adverse drug reactions were recorded.Results The standard scores of SDS and SAS significantly decreased after 8-week treatment in group A and group B (P<0.01), FPG, 2hPG and HbA1c significantly decreased in all groups (P<0.01,P<0.05),but the descending degree was more significant in group A and group B than in group C (P<0.05).Adverse drug reactions were less in group A than in group B (P<0.05).Conclusion Antianxiety and antidepression drugs effectively ameliorate anxious and depressive symptoms and are helpful to control blood glucose in patients with diabetes.