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Experimental torticollis in the marmoset produced by injection of 6-hydroxydopamine into the ascending nigrostriatal pathway |
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| Authors: | M.A Sambrook A.R Crossman P Slater |
| Affiliation: | 1. Department of Anatomy, Medical School, University of Manchester, Manchester, M13 9PT Great Britain;2. Department of Physiology, Medical School, University of Manchester, Manchester, M13 9PT Great Britain;3. Department of Neurology, University Hospital of South Manchester, West Didsbury, Manchester, M20 8LR Great Britain |
| Abstract: | Torticollis was observed in the marmoset following interruption of the ascending nigrostriatal dopaminergic pathway by injection of the specific catecholamine neurotoxin, 6-hydroxydopamine. It was possible to either accentuate or reverse the torticollis by manipulation of the relative dopamine activity of the two striata. The relationship between these findings and the etiology of torticollis in the primate is discussed. |
| Keywords: | DA dopamine GABA gamma-aminobutyric acid 6-OHDA Hbr 6-hydroxydopamine hydrobromide NA noradrenalin |
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