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Three new indole alkaloid derivatives from the roots of Murraya paniculata
Authors:Xiao-Ting Wang  Ke-Wu Zeng  Ming-Bo Zhao  Peng-Fei Tu
Affiliation:State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Abstract:Three new indole alkaloid derivatives, named paniculidines D?F (1?3), and six known analogs (4?9) were isolated from the roots of Murraya paniculata. The structures were elucidated on the basis of comprehensive HRESIMS, UV, IR, and NMR spectroscopic data analysis and comparison with the data reported in literature. The absolute configurations of new compounds were assigned via the determination of specific optical rotation, Mosher′s method, and ECD spectra. Compound 3 is the first heterodimer of C-N linked indole and coumarin derivatives.
Keywords:Rutaceae  Murraya paniculata  indole alkaloids  heterodimer
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