Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives |
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| Authors: | Yin-Lin Qin Lei Chen Wei He Mei Su Qiu Jin Zheng Fang |
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| Affiliation: | 1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Technology University, Nanjing 211816, China;2. Jiangsu Carephar Pharmaceutical Co., Ltd, Nanjing 210014, China;3. Department of Chemistry, Fudan University, Shanghai 200433, China |
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| Abstract: | A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury. |
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| Keywords: | Tanshinone IIA sulfonation slat-forming amidation anti-myocardial injury |
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