Isolation and structure elucidation of halymeniaol,a new antimalarial sterol derivative from the red alga Halymenia floresii |
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| Authors: | Srinu Meesala Pratima Gurung Krishanpal Karmodiya Parameswaran Subrayan Milind G. Watve |
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| Affiliation: | 1. Department of Biology, Indian Institute of Science Education and Research, Pune 411008, India;2. Department of Chemistry, CSIR-NIO, Dona Paula 403 004, India |
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| Abstract: | A new mono-hydroxy acetylated sterol derivative: 12β-hydroxy-3β, 15α, 16β-triacetoxy-cholest-5-en-7-one (halymeniaol) (1), and cholesterol (2) were isolated from the marine red alga Halymenia floresii. The structure of the compound 1 (halymeniaol) was established from its spectral data, derived from HRMS/MS and 2D NMR. Compound 1 exhibited growth inhibitory activity against chloroquine-resistant Plasmodium falciparum 3D7 strain with an IC50 of 3.0 μM. |
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| Keywords: | Algae sterols NMR & mass spectrometry natural products antimalarial activity |
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