大肠癌和癌旁粘膜中胃泌素,生长抑素变化的研究

临床观察大肠癌和癌旁粘膜中胃泌素，生长抑素及其分泌细胞的变化 ，探讨病人体内胃泌素、ＳＳ变化的原因和意义。方法：采用放射免疫法测定２６例大肠癌病人肿瘤和癌旁粘膜中胃泌素，生长抑素水平，并对其分泌细胞行免疫细胞化学观察。

A clinical study on the changes of gastrin, somatostatin in colorectal cancer and its surrounding mucosa

Purpose: To explore the reason and significance of the variation of gastrin and somatostatin (SS) in colorectal cancer patients through clinically observing the changes of gastrin, SS and their secretory cells in tumor and its surrounding mucosae. Method: The gastrin. SS levels in tumor and its surrounding mucosa were determined by RIA, and the gastrin, SS secretory cells in these tissues were observed by immunocytochemistry in 26 colorectal cancer patients. Results: Gastrin level in tumor and its surrounding mucosa was too low to be detected and there were no gastrin cells in those tissues. The mean SS level in cancer-distant mucosa (CDM, about 5 cm from the tumor) was very significantly lower than that in cancer-adjacent mucosa (CAM, 0-2 cm from the tumor), and higher than that in tumor (P<0.01). The mean SS levels both in the well differentiated and mucinous adenocarcinomas were significantly higher than those in moderately (P<0.01 and 0.05, respectively) and poorly (P<0.05) differentiated tumors. SS cells were not found in tumor. The form and location of SS cells in all tumor surrounding mucosae were similar to the normal. The mean SS cell number was very significantly higher in adjacent mucosae than in 4-6 cm mucosae (P<0.01). In CAMs, there was a very signifigant positive correlation between the SS levels and SS cell numbers (P<0.01). Conclusions: The elevation of SS level in CAM is mainly caused by the increase of SS cell number, which secrete more SS. The change of SS in colorectal cancer surrounding mucosa maybe play an important role in inhibiting the development of the tumor, and is a local defensive reaction in the body.