| 糖尿病肾病患者蛋白氧化损伤的研究 |
| |
| 引用本文： | 许娟,亓文波,杨洪云.糖尿病肾病患者蛋白氧化损伤的研究[J].泰山医学院学报,2009,30(6):407-409. |
| |
| 作者姓名： | 许娟 亓文波 杨洪云 |
| |
| 作者单位： | 1. 泰山医学院附属泰安医院内分泌科,山东,泰安,271000
2. 泰山医学院附属医院检验科,山东,泰安,271000 |
| |
| 摘 要： | 目的检测糖尿病肾病不同阶段患者血清晚期氧化蛋白产物水平及蛋白羰基含量，评价蛋白氧化损伤程度。方法根据24小时尿白蛋白定量将糖尿病患者分为单纯糖尿病组（DM组）、糖尿病早期肾病组（DN1组）、糖尿病肾病组（DN2组），并设健康对照组（NC组），检测各组血清晚期氧化蛋白产物（advancedoxidationproteinproducts，AOPPs）、蛋白质羰基含量（proteincarbonyl，pco）水平。结果DM组血AOPPs、PCO较NC组明显升高，DN组患者血AOPPs、PCO较DM组明显升高，且随着肾病的进展AOPPs、PCO逐渐升高，组间差异均具有统计学意义（P〈0．05）。结论糖尿病肾病患者蛋白氧化损伤较单纯糖尿病患者明显加重，而且随着糖尿病肾病的进展，蛋白氧化损伤进一步加重，蛋白氧化损伤产物积累增多。
|
| 关 键 词： | 糖尿病肾病 蛋白氧化损伤 晚期氧化蛋白产物 蛋白羰基 |
Study on oxidative protein damage in diabetic nephropathy |
| |
| XU Juan,QI Wen-bo,YANG Hong-yun.Study on oxidative protein damage in diabetic nephropathy[J].Journal of Taishan Medical College,2009,30(6):407-409. |
| |
| Authors: | XU Juan QI Wen-bo YANG Hong-yun |
| |
| Institution: | XU Juan ,QI Wen-bo , YANG Hong-yun ( 1. Dept. of Endocrinology, Taian City Central Hospital, Taian 271000, China; 2. Dept. of Clinical Laboratory, Affiliated Hospital of Taishan Medical College, Taian 271000, China) |
| |
| Abstract: | Objective: To study oxidative protein damage in diabetic nephropathy patients through determination of ser-um AOPPs and PCO levels. Methods: Diabetic patients were divided into three groups according to 24h urinary albumin de-termination, serum AOPPs and PCO levels of these patients and normal controls were measured. Results: Serum AOPPs and PCO levels were significantly higher in diabetic patients( DM ,DN1 ,DN2) than those in the controls, and the levels be-came significantly higher as nephropathy developed (P<0.05). Conclusion: Oxidative protein damage increases in diabetic patients, and becomes more serious when complicated with nephropathy, and more products of oxidative protein damage are accumulated simultaneously. |
| |
| Keywords: | diabetic nephropathy oxidative protein damage advanced oxidation protein products protein carbonyl |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
