Targeting death receptor induced apoptosis and necroptosis: a novel therapeutic strategy to prevent neuronal damage in retinal detachment |
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Authors: | Dong K Sun X |
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Affiliation: | Department of Ophthalmology, Affiliated First People’s Hospital of Shanghai JiaoTong University School of Medicine, Shanghai, China |
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Abstract: | Retinal detachment (RD) is a common cause of human visual impairment. Detachment of photoreceptors from the retinal pigment epithelium causes photoreceptor loss and subsequent vision decline. Death receptor (DR)-induced apoptosis play critical role in activating apoptosis in photoreceptor cells. Z-VAD-FMK inhibits the DR-induced retinal neuronal apoptosis but promotes neuronal death through necroptosis pathway, an alternative programmed cell death, which can be inhibited by Nec-1. Thus, we may achieve a better result by simultaneous inhibition of DR-induced apoptosis and necroptosis, which provides us with a new direction in the treatment of RD. |
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Keywords: | TRADD, tumor necrosis factor receptor type 1-associated DEATH domain protein TRAF2, TNF receptor-associated factor 2 cIAP1, cellular inhibitor of apoptosis 1 RIP, receptor-interacting protein TRAIL, TNF-related apoptosis-inducing ligand TNF, tumor necrosis factor FasL, Fas ligand NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells Z-VAD-FMK, benzyloxycarbonyl-Val-Ala-DL-Asp(O-methyl)-fluoromethylketone |
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