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| 胃癌组织中多药耐药基因的表达特点及其对化疗的指导意义 | |
| 引用本文： | 魏学明,顾国利,任力,王石林,李德昌,宁守斌,熊梅.胃癌组织中多药耐药基因的表达特点及其对化疗的指导意义[J].胃肠病学和肝病学杂志,2009,18(11). |
| 作者姓名： | 魏学明 顾国利 任力 王石林 李德昌 宁守斌 熊梅 |
| 作者单位： | 1. 中国人民解放军空军总医院普通外科,北京,100142 2. 中国人民解放军空军总医院病理科,北京,100142 3. 中国人民解放军空军总医院消化内科,北京,100142 |
| 摘 要： | 目的探讨5种多药耐药基因产物在胃癌组织中的表达特点及其对胃癌化疗的指导意义。方法应用免疫组化SP法联合检测48例胃癌组织和10例正常胃黏膜中胎盘型谷胱甘肽-S-转移酶(GST-π)、P-糖蛋白(P-gp)、拓扑异构酶Ⅱ(Topo-Ⅱ)、胸苷酸合成酶(TS)、多药耐药相关蛋白(MRP)的表达,并结合其临床病理资料进行回顾性分析。结果胃癌组织中GST-π、P-gp、Topo-Ⅱ、TS、MRP的阳性表达率依次为72.9%(35/48)、56.3%(27/48)、83.3%(40/48)、41.7%(20/48)和39.6%(19/48),与正常胃黏膜组织比较差异显著。其表达与病人的性别、年龄和肿瘤的部位、大小、侵袭深度、淋巴结转移均无关,而与肿瘤的分化程度、组织学类型密切相关。结论GST-π、P-gp、Topo-Ⅱ、TS、MRP的高表达可能是胃癌多药耐药产生的基础。多药耐药基因产物的联合检测有助于判断胃癌病人的预后;也对化疗方案的制定和药物选择有指导意义。 |
| 关 键 词： | 胃癌 多药耐药性 化疗 免疫组化 |
Expressions of multidrug resistance genes in gastric cancer tissues and their directive significance for the chemotherapy of gastric cancer |
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| WEI Xueming,GU Guoli,REN Li,WANG Shilin,LI Dechang,NING Shoubin,XIONG Mei.Expressions of multidrug resistance genes in gastric cancer tissues and their directive significance for the chemotherapy of gastric cancer[J].Chinese Journal of Gastroenterology and Hepatology,2009,18(11). | |
| Authors: | WEI Xueming GU Guoli REN Li WANG Shilin LI Dechang NING Shoubin XIONG Mei |
| Institution: | 1.Department of General Surgery; 2.Department of Pathology; 3.Department of Gastroenterology; General Hospital of the Air Force; PLA; Beijing 100142; China; |
| Abstract: | Objective To detect the expressions of multidrug resistance genes in gastric cancer tissues,including glutathione-s-transferase π(GST-π),P-glycoprotein(P-gp),topoisomerase Ⅱ(Topo-Ⅱ),thymidylate synthase(TS),multidrug resistance related protein(MRP),and to analyze their directive significance for the chemotherapy of gastric cancer.Methods The expressions of GST-π,P-gp,Topo-Ⅱ,TS,MRP in sample of 48 gastric cancer tissues and 10 normal gastric mucosa were detected by SP immunohistochemical stain method.The cor... |
| Keywords: | Gastric cancer Multidrug resistance Chemotherapy Immunohistochemistry |
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