造影剂对2型糖尿病患者氧化应激的影响

目的：研究造影剂对2型糖尿病患者氧化应激的影响。方法：15例行静脉肾盂造影的2型糖尿病患者,应用的造影剂为低渗非离子造影剂碘海醇,检测造影前和造影后2 d、5 d、10 d血清丙二醛（MDA）、晚期蛋白质氧化物（AOPP）和超氧化物歧化酶（SOD）的水平。结果：造影后2 d,患者氧化应激水平均较造影前增高（P〈0.05）;造影后5 d,氧化应激水平进一步增高（P〈0.01）;造影后10 d,氧化应激水平均恢复至造影前水平（P〉0.05）。结论：造影剂可一过性增强2型糖尿病患者氧化应激水平。

Effects of Contrast Medium on Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Objective： To investigate the effects of contrast medium on oxidative stress in patients with type 2 diabetes mellitus.Methods： Thirty patients with type 2 diabetes mellitus who were performed arteriography were enrolled.All patients received hypotonic nonionic contrast agent iohexol.Serum malondialdehyde（MDA）,advanced oxidation protein products（AOPP） and superoxide dismutase（SOD） were determined on the day before and 2 days,5 days,10 days after exposure to contrast medium.Results： Two days after contrast medium administration,the levels of oxidative stress in patients were significantly increased.Five days after contrast medium administration,the levels of oxidative stress in patients were significantly increased furthermore.However,ten days after contrast medium administration,the abilities of oxidative stress in patients returned to original levels.Conclusion： Contrast medium could transiently strengthen the abilities of oxidative stress in patients with type 2 diabetes mellitus.