妊娠合并梅毒临床诊治探讨

目的：探讨妊娠合并梅毒对围生儿预后的影响。方法：根据是否行抗梅毒治疗,将113例血清学检查确诊为梅毒的孕妇分为全疗程治疗组（64例）和未治疗组（49例）,比较两组孕妇的妊娠结局、围生儿预后及新生儿先天梅毒的发生情况。结果：治疗组足月分娩率90.62%,而未治疗组仅为69.39%（P〈0.01）;治疗组早产及死胎的发生率分别为4.69%及4.69%,明显低于未治疗组20.41%及10.20%（P〈0.01）;治疗组分娩的正常新生儿者占76.56%,而未治疗组仅占16.93%（P〈0.01）。结论：妊娠合并梅毒孕妇及早、规范治疗可以明显改善妊娠结局和围生儿预后,降低围生儿死亡率及先天梅毒的发生。

Clinical Treatment of Pregnancy Complicated with Syphilis

Objective：To investigate the effect of pregnant women with syphilis on perinatal prognosis.Method：113 pregnant women with syphilis by serological assays were divided into two groups,64 cases in treatment group were treated with a full course of anti-syphilis therapy and 49 cases in untreated group.The pregnant outcomes and perinatal progosis and congenital syphilis were compared between two groups.Result：In treatment group,term delivery reached 90.62%,but 69.39% in untreated group（P〈0.01）.The rate of premature birth and fetal intrauterine death was 4.69% and 4.69% in treatment group,which was much lower than 20.41% and10.20% in untreated group（P〈0.01）.The normal rate of neonates was 76.56% in treated group,which was significantly higher than that of 16.93% in untreated group（P〈0.01）.Conclusion：Early and regular treatment to pregnant women with syphilis could significantly improve the pregnant outcomes and perinatal prognosis,and also decrease the rate of the perinatal death and incidence of congenital syphilis.