| 腺苷蛋氨酸治疗药物性肝损伤效果的系统评价 |
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| 引用本文： | 赵攀,段光锋,杜丽,徐东平,唐彦,韩玉坤. 腺苷蛋氨酸治疗药物性肝损伤效果的系统评价[J]. 胃肠病学和肝病学杂志, 2011, 20(4): 341-344 |
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| 作者姓名： | 赵攀 段光锋 杜丽 徐东平 唐彦 韩玉坤 |
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| 作者单位： | 1. 解放军第302医院肝衰竭诊疗与研究中心病毒性肝炎研究室,北京,100039
2. 第二军医大学卫勤系信息室 |
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| 摘 要： | 目的系统评价腺苷蛋氨酸治疗药物性肝损伤的效果。方法检索2010年9月以前在CBMdisk、CNKI全文数据库、万方中文期刊全文数据库、维普中文期刊全文数据库公开发表的有关腺苷蛋氨酸治疗药物性肝损伤的随机对照临床研究。采用χ2检验分析研究间的异质性,以加权平均数为疗效分析统计量进行合并分析并绘制森林图。疗效判定指标包括血清总胆红素、ALT和γ-谷氨酰转肽酶。结果共检索到126篇文献,经筛选和评价后最终纳入4篇文献。Meta分析结果显示,腺苷蛋氨酸组（治疗组）血清总胆红素（P=0.003）和ALT（P=0.0002）的均数低于对照组,差异有统计学意义;但两组γ-谷氨酰转肽酶的均数差异无统计学意义（P=0.07）。结论腺苷蛋氨酸可显著降低药物性肝损伤患者的血清总胆红素和ALT,但对γ-谷氨酰转肽酶的影响不显著。
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| 关 键 词： | 腺苷蛋氨酸 药物性肝损伤 Meta分析 |
Systematic evaluation on the efficacy of ademetionine in patients with drug-induced liver injury |
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| ZHAO Pan,DUAN Guangfeng,DU Li,XU Dongping,TANG Yan,HAN Yukun. Systematic evaluation on the efficacy of ademetionine in patients with drug-induced liver injury[J]. Chinese Journal of Gastroenterology and Hepatology, 2011, 20(4): 341-344 |
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| Authors: | ZHAO Pan DUAN Guangfeng DU Li XU Dongping TANG Yan HAN Yukun |
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| Affiliation: | ZHAO Pan1,DUAN Guangfeng2,DU Li1,XU Dongping1,TANG Yan1,HAN Yukun1 1.Viral Hepatitis Research Laboratory in the Liver Failure Therapy and Research Center,Chinese PLA 302 Hospital,Beijing 100039,2.Information Research Division,Second Military Medical University,China |
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| Abstract: | Objective To evaluate the efficacy of ademetionine in patients with drug-induced liver injury.Methods Articles(randomized controlled clinical trials) published in CBMdisk,CNKI(National Knowledge Infrastructure),Wangfang database and Vip database before September-2010 about the efficacy of ademetionine in patients with drug-induced liver injury were searched.Heterogeneity was examined by Chi-square test,the weighted mean difference was calculated and forest-graph was drawn.The evaluated index contained serum... |
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| Keywords: | Ademetionine Drug-induced liver injury Meta analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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