浙江省肺结核病人耐药特征

目的 掌握浙江省肺结核病人耐药特征，衡量全省结核病控制实施效果。方法 1997年20个监测点的门诊结核病人进行耐药测定，药敏试验采用绝对浓度间接法。结果 709例肺结核病人的初始耐药率为18.6%，对一药的耐药最高 (10.5%)。初治敏感与耐药病人的化疗效果几乎同样好。复治耐药率为68.5%，以耐RH二药最高 (38.7%)。复治耐药病人的化疗效果较差，治愈率为39.5%。结论 浙江省结核病控制工作规范化起步较晚，今后的工作重点对初治涂阳病例采用合理化疗方案和DOTS管理。

The character of drug resistance of pulmonary tuberculosis cases in Zhejiang

Objective To evaluate the effect of NTP carried out in Zhejiang province and to find out a set of surveillant system for susceptibility tests.Methods All the cases from 20 clusters had been done susceptibility tests from January to June 1997 with absolute concentration method.Results Among 709 cases,the rate of initial resistance was 18.6%,the resistant rate to one drug was the highest(10.5%);the rae of acquired resistance was 68.5%,the resistant rate to isoniazid and rifampicin was the highest(38.7%).The effects of chemotherapy were good not only in new susceptibility cases but also in new drug resistant cases.The effect of chemotherapy to retreatment of drug resistant cases was worse,the cure rate was 39.5%.Conclusion NTP had not been fully carried out in Zhejiang province in the past.Adopting DOTS and standard Chemotherapy to new smear positive cases will be carried out emphatically in the future.