| 人参二醇组皂甙对失血性休克犬血管紧张素Ⅱ与去甲肾上腺素的影响 |
| |
| 引用本文： | 林桦,王忠山,计国义,赵丹,赵雪俭.人参二醇组皂甙对失血性休克犬血管紧张素Ⅱ与去甲肾上腺素的影响[J].吉林大学学报(医学版),1990(3). |
| |
| 作者姓名： | 林桦 王忠山 计国义 赵丹 赵雪俭 |
| |
| 作者单位： | 白求恩医科大学病理生理教研室
(林桦，王忠山，计国义，赵丹)，白求恩医科大学病理生理教研室(赵雪俭) |
| |
| 摘 要： | 杂种犬43只,参照体重随机分为失血性休克人参预治疗组(HSG),失血性休克地塞米松预治疗组(HSD),各14只,其余15只为失血性休克组(HS)组。HSG组静脉注射人参二醇组皂甙溶液25mg/kg。HSD组肌注地塞米松1mg/kg,均于放血前1h给药。经颈动脉放血使平均动脉压降至5.3kPa,观察5h。结果表明,5h存活率,HSG组为92.9％,HSD组为76.9％(其中2只死于胃肠道弥漫性出血),HS组为66.7％;血浆血管紧张素Ⅱ(AⅡ)含量的变化显示,地塞米松和人参二醇组皂甙抑制失血后AⅡ含量的增高;血清去甲肾上腺素(NE)的测定结果表明,人参二醇组皂武和地塞米松可阻止失血性休克时血清NE含量的持续增高。
|
| 关 键 词： | 失血性休克 犬 人参二醇组皂甙 地塞米松 去甲肾上腺素 血管紧张素Ⅱ |
EFFECT OF PANAXADIOL SAPONINS ON A II AND NE IN EXPERIMENTAL HEMORRHAGIC SHOCK |
| |
| Lin Hua,Wang Zhongshan,Ji Guoyj,Zhao Dan,Zhao Xuejian.EFFECT OF PANAXADIOL SAPONINS ON A II AND NE IN EXPERIMENTAL HEMORRHAGIC SHOCK[J].Journal of Jilin University: Med Ed,1990(3). |
| |
| Authors: | Lin Hua Wang Zhongshan Ji Guoyj Zhao Dan Zhao Xuejian |
| |
| Institution: | Department of Pathophysiology |
| |
| Abstract: | Forty-three mongrel dogs subjected to hemorrhagic hypotension at a mean arterial pressure of 5.3 kPa for 5 hours were randomly divided into one group (n = 14) pretreated with 25mg/kg of panaxadiol saponins (HSG) , one group (n = 14) pretreated with 1 mg/kg of dexamethasone (HSD) and one group (n-15) without any pretreatment (HS) .The results indicated that the survival rate at the 5th hour in HSG, HSD and HS groups were. 92.9%, 76.9% and66.7% respectively, and the usual increases in serum angiotension II andnorepiuephrine during the hemmorhagic shock were inhibited by panaxadiolsaponins and dexamethasone. |
| |
| Keywords: | Hemorrhagic shock Dogs Panaxadiol saponins Dexamethasone Norepinephrine Angiotension II |
| 本文献已被 CNKI 等数据库收录！ |
|
