Expression of complement messenger RNAs by human endothelial cells |
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| Authors: | Andis Klegeris Christopher J Bissonnette Katerina Dorovini-Zis Patrick L McGeer |
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| Affiliation: | Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, V6T 1Z3, Vancouver, BC, Canada. |
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| Abstract: | This study evaluated complement mRNA expression in human brain microvessel endothelial cells (HBMEC), human umbilical vein endothelial cells (HUVEC), and cells of the human derived ECV304 line. Cerebral endothelial cells and HUVEC expressed detectable levels of complement gene mRNAs for the C1q B-chain, C1r, C1s, C2, C3, C4, C5, C7, C8 gamma-subunit and C9. In addition to C6 mRNA, C1q and C9 were not detected in ECV304 cells. These results indicate that endothelial cells may be a source of complement proteins in brain and other organs of the body. |
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| Keywords: | Complement classical pathway Human brain Inflammation Polymerase chain reaction Vascular endothelium |
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