喷他佐辛超前镇痛用于开胸手术术后肋间神经冷冻患者效果观察

目的 观察喷他佐辛超前镇痛用于开胸手术后肋间神经冷冻患者的效果.方法 60例进行开胸手术患者(ASA Ⅰ～Ⅱ级)随机分成两组,每组30例,A组切皮前10 min静脉缓慢推注喷他佐辛0.5 mg/kg;B组切皮前静脉推注0.9％生理盐水2ml.观察两组患者的呼吸恢复时间、睁眼时间、拔管时间；采用视觉模拟评分法(VAS)对患者术后1h、4h、8h、24 h进行疼痛程度评分；采用舒适度评分法(BCS)对患者术后1h、4h、8h、24 h进行镇静评分；比较两组患者术后7日内的不良反应.结果 两组患者的呼吸恢复时间、睁眼时间、拔管时间差异无显著性；A组病人各时段的VAS评分均低于B组(P＜0.05); A组患者BCS评分高于B组(P＜0.05).结论 喷他佐辛超前镇痛有助于减轻开胸手术后肋间神经冷冻患者的疼痛不适,且不会导致患者苏醒延迟.

Observation on the effect of Pentazocine pre-emptive analgesia in patients receiving intercostal nerve cryoanalgesia after post-thoracotomy

Objective To observe the effect of pentazocine pre-emptive analgesia in patients receiving inter- costal nerve cryoanalgesia after post-thoracotomy.Methods 60 patients with elective thoracotomy （ASA grade I to grade Ⅱ ） were randomly divided into pre-emptive analgesia group （group A） and the control group （group B）. Group A （n=-30） received slow bolus injection of pentazocine 0.5 mg/kg 10 minutes before the beginning of operation. Patients in group B （n=30） were injected with saline （0.9%, 2ml）. Then we recorded the spontaneous breathing recovery time, eyes open time and extubation time and analgesia. Visual analong scale scores （VAS） were used for pain degree score evaluation, and also BCS at 1, 4, 8, 24 hours after operation. We recorded the incidence of disadvantage between the two groups.Results There was no significant difference on the spontaneous breathing recovery time, eyes open time and extubation time between the two groups. VAS of group A was lower than that of group B （P〈0.05）. BCS of group A was higher than that of group B （P〈0.05）. The incidence of disadvantage in group A was lower than that in group B （P〈0.05）.Conclusion Preoperative application of pentazocine 0.5 mg/kg can effectively reduce the pain of post-thoracotomy patients receiving intercostal nerve cryoanalgesia and will not lead delayed recovery.