原发性骨质疏松发病机制与胰岛素样生长因子关系的研究进展

在过去的几年时间里,关于胰岛素样生长因子系统在骨骼再建中的作用得到了充分的肯定.在这里我们应用充分的证据说明由骨细胞所产生的IGF-1和IGF-2在调节成骨细胞和破骨细胞中所起的作用,另外,我们也回顾了几个实验室所做的关于胰岛素样生长因子系统的实验结果.有证据表明,其他调节骨代谢的通过IGF系统发挥作用.骨骼局部的IGF-1和IGF-2在骨再建中的作用众所周知,但是关于循环系统中IGF 的作用仍然不是十分明了.有新的研究结果表明血清中的生长因子也起到了一定的作用,最后我们回顾了目前比较公认的重组IGFs对骨再建的作用,然而,关于IGFs对骨值疏松的最终的治疗效果仍有待于进一步研究.

Research progress on correlation between primary osteoporosis and the pathogenesis of insulin-like growth factors

ObJective In the last five years significant progress has been made in defining the role of insulin- like growth factors （IGFs） in the process of bone remodeling. In this paper, we present critical evidence that IGF- I and IGF- II are produced by bone cells and regulate specific osteoclastic functions. In addition, we review work from several labora- tories establishing the role of the skeletal IGF binding proteins as an integral component of a unique IGF regulatory system. According to related evidences, the bone remodeling process may exert their effects through the I GF regulatory system. In contrast to the well-defined local action of IGF-I and IGF- II on the skeleton, the relationship between circulating IGF-I and bone remodeling is less certain. Newer research results show that the potential utility of serum growth factor measure- ments have certain effects in clinical states. Finally, this paper presents an overview of the most current efforts to stimulate bone formation using recombinant IGFs. However, work on the beneficial aspects of IGFs for the skeleton remains prelimi- nary at best with the eventual therapeutic role of IGF-I in osteoporosis yet to be defined.