抗抑郁治疗对高血压伴抑郁症患者血压和生活质量的影响

[目的]探讨抗抑郁药物西酞普兰联合心理康复对高血压并抑郁症患者血压和生活质量的影响.[方法]106例伴有抑郁障碍的原发性高血压患者随机分为对照组和观察组各53例,对照组予常规治疗,观察组在对照组的基础上加用抗抑郁药物西酞普兰联合心理康复治疗,观察两组患者治疗前后血压、抑郁症状与生活质量的变化情况.[结果]治疗6周后,观察组总有效率为92.45％,对照组为71.70％,差异有显著性(P＜0.05);两组患者的收缩压、舒张压及HAMD评分均较治疗前明显下降(P＜0.05),观察组下降幅度明显大于对照组(P＜ 0.05);观察组患者治疗后躯体功能、心理功能、社会功能、物质功能及生活质量总分均明显升高(P＜0.05),对照组治疗前后变化不明显(P＞0.05).[结论]对原发性高血压病伴有抑郁症患者在常规治疗的基础上给予抗抑郁药物治疗与心理康复,能有效改善患者的生活质量,明显提高患者血压控制率.

Effect of the antidepressant treatment to the blood pressure and quality of life of for hypertension patients with depression

Objective To discuss the effect of antidepressant drug citalopram combined with psychological rehabilitation treatment in reducing high blood pressure and affecting the quality of life （QOL） to the hypertension patients with depression. Methods 106 primary hypertension patients with depressive disorder were selected, and randomly divided into two groups, 53 cases in the control group were treated by conventional therapy, and on the basis of the treatment of the control group, 53 cases in the observation group were treated by antidepressant medication citalopram combined with psychological rehabilitation, and then we observed their blood pressure, depressed symptom and the changes of the patients＇ QOL. Results After 6 weeks, the total effective rate of the observation group was 92.45%, and the control group was 71.70%, there was statistical significant difference between them（P〈 0.05）. All the patients＇ systolic pressure, diastolic pressure and HAMD score were declined a lot than before （P〈 0.05）, and the observation group was better than the control group（P〈 0.05）.The somatic function, mental function, social function, matter function and total points of the QOL in the observation group were all rising a lot（P〈 0.05）, but the control group had no change（P〉 0.05）. Conclusion For the primary hypertension patients with depressive disorder, on the basis of the conventional therapy , addingthe antidepressant medication citalopram combined with psychological rehabilitation will ameliorate the patients＇ QOL and improve the control rate of the patients＇ s blood pressure.