阻塞性睡眠呼吸暂停患者体重指数和年龄与呼吸暂停低通气指数相关性研究

目的]探讨阻塞性睡眠呼吸暂停( OSA)患者体重指数和年龄与呼吸暂停低通气指数(AHI)的相关性.方法 对2985例经睡眠多导图(PSG)检查确诊为OSA的患者的体重指数和年龄与呼吸暂停低通气指数进行相关性分析.根据患者年龄分为青年组(18 -44岁)、中年组(45～59岁)和老年组(60～80岁),根据患者体重指数分为正常体重组( 18.5 ～ 23)、超重组(24～27)和肥胖组(＞28),比较不同年龄组和不同体重指数组OSA患者PSG的结果.结果 OSA患者AHI与体重指数呈正相关(r=0.445,P＜0.001),与患者年龄呈负相关(ι=-0.105,P＜0.05).肥胖组AHI( 51.8±27.0)次/h]明显大于超重组( 37.6±23.5)次/h]和正常组( 27.5±21.5次/h)],三组之间的比较差异有统计学意义(P＜0.05).老年组AHI( 37.7±23.3)次/h]明显小于中年组( 41.1±25.2)次/h]和青年组( 45.0±28.6)次/h],不同组之间的比较差异有统计学意义(P＜0.05).结论OSA患者AHI与BMI呈正相关,肥胖是OSA重要危险因素.

The association of BMI and age with apnea-hypopnea index in patients with obstructive sleep apnea

Objective To explore the association of body mass index （ BMI ） and age with apnea-hypopnea index （ AHI ） in patients with obstructive sleep apnea （ OSA ）. Methods Retrospectively studied 2985 patients with OSA comfirmed by polysomnograhy during the period of 2001 to 2011. The patients were dividing into young adult group （ aged 18 to 44 ）, middle-age group （ aged 45 to 59 ）, and elderly group （ aged 60 to 80 ） basing on their age, and divided into normal weight group （ 18.5 - 23 ）, overweight group （ 24 - 27 ）, and obesity group （ 〉 28 ） basing on their BMI. The relationship of AHI with BMI and age was analyzed. Results AHI was positively correlated with BMI （ r= 0.445, P 〈 0.001 ） and age was negatively correlated with AHI （ r = -0.105, P 〈 0.05 ）. AHI was significantly greater in the obesity group （ 51.8 ± 27.0 / h ） than in the overweight group （ 37.6 ± 23.5 / h ） and normal group （ 27.5 ± 21.5 / h ）;, the difference was statistically significant among these three groups （ P〈 0.05 ）. AHI was significantly less in the elderly group （ 37.7 ± 23.3 / h ） than in the middle-age group （ 41.1 ± 25.2 / h ） and youth adult group （ 45.0 ± 28.6 / h ）; the difference was statistically significant among these groups （ P 〈 0.05 ）. Conclusions Apnea-hypopnea index is positively associated with body mass index in patients with obstructive sleep apnea. Obesity is an important risk factor for obstructive sleep apnea.