学生献血前血液初筛省略ALT测定的可行性探讨

目的 探讨在学校集体献血活动中,学生献血前血液初筛省略丙氨酸氨基转移酶(ALT)测定的可行性.方法 所有的献血者分为两大类:参加学校集体献血活动的学生献血者和除学生献血者外的其它献血者.ALT测定策略:其它献血者2007至2011年进行献血前初筛和采血后复检；学生献血者2007至2009年进行献血前初筛和采血后复检,而2010、2011年献血前省略初筛,仅采血后复检.结果判断:ALT＞40 U/L为阳性.统计分析2007至2009年学生献血者与其它献血者初筛ALT的阳性率间的差异、学生献血者献血前初筛ALT的阳性率3年间的差异,2007至2011年学生献血者献血后复检ALT的阳性率5年间的差异.结果 2007至2009年,学生献血前ALT初筛的阳性率分别为:0.18％、0.20％、0.18％,其它献血者献血前ALT初筛的阳性率分别为:3.82％、4.00％、3.91％,两者献血前ALT初筛每年的阳性率间差异均有统计学意义(P＜0.05)；学生献血前ALT初筛的阳性率3年间差异无统计学意义(P＞0.05).2007至2011年,学生献血后ALT复检的阳性率非常低,分别为:0.15％、0.12％、0.12％、0.20％、0.20％,5年间差异无统计学意义(P＞0.05).结论 在学校集体献血活动中,学生献血者献血前初筛省略ALT测定对血液最终复检ALT的阳性率影响不大,与献血前初筛ALT的效果基本持平,献血前血液初筛可省略ALT的测定.

The feasibility of primary blood screening without ALT detection before blood donation in students

Objective To explore the feasibility of primary blood screening without ALT detection before blood donation in students. Methods All the blood donors were divided into two groups： student donors and other donors,Methods Primary ALT screening before blood donation and re-detection were performed from 2007 to 2011 in other donors and from 2007 to 2009 in student donors. And the student donors received only detection after donation but no primary screening in 2010 and 2011. ALT of 〉 40U/L was the positive result. The differences of positive rate of primary ALT screening between the student donors and other donors, the differences of positive rates in three years in student donors, and the differences of positive rate of re-detection of ALT in five years （ from 2007 to 2011 ） were statistically analyzed. Results The positive rate of primary ALT screening was 0.18% in 2007, 0.20% in 2008, and 0.18% in 2009 for student donors, and 3.82%, 4.00%, and 3.91% for other donors, with a significant difference between the student and other donors in each year （ P〈 0.05 ）. There were no significant differences in the positive rate of ALT screening in student donors from 2007 to 2009 （ P〉 0.05 ）. The positive rate of re-detection of ALT in student donors from 2007 to 2011 was very low （ 0.15%, 0.12%, 0.12%, 0.20%, and 0.20%, respectively）, with no significant difference among the five years. Conclusions In the activities of school collective donation, primary blood screening without ALT detection before blood donation in student donors has little effect on the final positive rate of ALT re-detection, basically equalling to the positive rate of primary screening, so ALT detected can be skipped in primary blood screening before donation.