| 玉米须中抑制黄嘌呤氧化酶活性组分的筛选及其作用 |
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| 引用本文： | 姜彤伟,徐建,王晓明,陈雪松,邱智东.玉米须中抑制黄嘌呤氧化酶活性组分的筛选及其作用[J].吉林大学学报(医学版),2011,37(3):433-436. |
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| 作者姓名： | 姜彤伟 徐建 王晓明 陈雪松 邱智东 |
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| 作者单位： | 长春中医药大学药学院,吉林,长春,130117;吉林省修正药业集团,吉林,长春,130012;吉林大学第一医院心内科,吉林,长春,130021;吉林省创智医药开发有限公司 |
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| 基金项目： | 国家科技部重大新药创制基金资助课题(2009ZX09103-348) |
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| 摘 要： | 目的:提取玉米须中具有抑制黄嘌呤氧化酶(XOD)作用的活性组分,为进一步开发治疗痛风的中药新药提供依据.方法:通过测定黄嘌呤-黄嘌呤氧化酶体系产生尿酸和超氧离子的生成量,得出玉米须不同溶剂提取物(乙醚提取物、乙酸乙酯提取物、正丁醇提取物和水提取物)及不同溶剂(水和10%、30%、50%、70%、90%乙醇)纯化得到的活...
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| 关 键 词： | 玉米须 痛风 黄嘌呤氧化酶 |
| 收稿时间： | 2010-09-06 |
Screening of active ingredient of Stigmata maydis inhibiting xanthine oxidase and its effect |
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| JIANG Tong-wei,XU Jian,WANG Xiao-ming,CHEN Xue-song,QIU Zhi-dong.Screening of active ingredient of Stigmata maydis inhibiting xanthine oxidase and its effect[J].Journal of Jilin University: Med Ed,2011,37(3):433-436. |
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| Authors: | JIANG Tong-wei XU Jian WANG Xiao-ming CHEN Xue-song QIU Zhi-dong |
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| Institution: | （1.School of Pharmacy, Changchun University of Chinese Medicine,Changchun 130117|China；2. Jilin Province Xiuzheng Pharmaceutical Group|Changchun 130012|China；3.Department of Cardiology,First Hosptal,Jilin University|Changchun 130021|China） |
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| Abstract: | Objective To extract the active ingredient of Stigmata maydis for inhibiting the xanthine oxidase(XOD)and provide the basis for the further development of new Chinese medicine in treatment of gout.Methods The production of uric acid and superoxide generation were detemined,and the inhibitory rates of XOD after treated with different solvent extraction and different solvent depuration of Stigma maydis were calculated,then the data was compared with positive control allopurinol.Results Compared with other gro... |
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| Keywords: | Stigma maydis gout xanthine oxidase |
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