Role of ABC transporters in cancer chemotherapy |
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| Authors: | Sun Yue-Li Patel Atish Kumar Priyank Chen Zhe-Sheng |
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| Affiliation: | 1Department of Pharmaceutical Sciences,College of Pharmacy and Allied Health Professionals,St.John’s University,Jamaica,NY 11439,USA;2State Key Laboratory of Oncology in South China;3Department of Medical Oncology,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 51006,P.R.China. |
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| Abstract: | Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR. |
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| Keywords: | ABC transporter multidrug resistance(MDR) ABCB1 multidrug resistance protein(MRP) ABCG2 |
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