成人Still病合并肝功能损害33例临床分析

目的探讨成人Still病（ASD）合并肝功能损害的临床特点及治疗对策。方法对1997年12月-2007年2月在我院诊治的38例ASD患者进行回顾性调查分析。结果肝损发生率为86．8％（33／38例），女性ASD患者更易出现肝损。肝损程度与ASD患者的病程、血沉显著相关，与年龄、白细胞总数无显著相关。肝损临床症状不典型，在正规使用糖皮质激素治疗2～6周后肝功能损害明显缓解。结论ASD中肝损发生率高，以丙氨酸氨基转移酶（ALT）升高为主要表现，糖皮质激素治疗预后好。

Clinical analysis of 33 cases of adult Still's disease associated with liver injury

Objective To explore the characteristic of liver injury in patients with adult Still＇s disease（ASD）. Methods Clinical records of 38 hospitalized patients with ASD from Dec. 1997 to Feb. 2007 were surveyed retrospectively. Results The incidence of liver injury was 86.8%（33/38）. Liver injury was found more in female than male. The severity of liver injury was significantly correlated with course, ESR, but not with age or the counts of WBC. Clinical symptoms of liver injury were atypical. After treatments by glucocorticosteroid for 2 to 6 weeks, liver function was obviously improved. Conclusion ASD is usually associated with liver injury, which always with good prognosis. The abnormal rise of ALT is the main characteristic of liver injury.