脑脓肿扩散加权成像与多体素氢质子波谱研究

目的：探讨磁共振扩散加权成像（DWI）与磁共振氢质子波谱成像（^1H-MRS）技术联合应用对脑脓肿的诊断价值。方法：对11例脑脓肿患者行DWI（SE-EPI序列）和多体素点分辨波谱分析法（PRESS-SI序列）MRS检查，并使用随机分析软件包Functool2进行图像分析和处理，获得病灶的表观扩散系数（ADC）图和波谱图，比较DWI和MRS对脑脓肿的诊断价值。结果：9例脑脓肿于DWI上呈高信号，2例为混杂信号。MRS上10例检测到氨基酸（AA）峰，其中2例脓液培养见厌氧茵生长者波谱图上可见乙酸（Ac）峰和琥珀酸（Suc）峰。结论：应联合应用DWI和^1 H—MRS对脑脓肿进行诊断和鉴别诊断。

Role of Diffusion Weighted Imaging (DWI) and 1H-MRS in the Diagnosis of Brain Abscess

Objective:To investigate the value of diffusion weighted imaging (DWI) and 1 H-MRS in the diagnosis of brain abscess. Methods: 11 patients with brain abscess had DWI and 1 H-MRS using 1. 5T MR scanner were retrospectively analyzed. DWI was performed using SE-EPI sequence and PRESS-SI sequence was used for 1 H-MRS. Apparent diffusion coefficient (ADC) values and metabolite patterns observed at 1 H-MRS were obtained by Functool 2. The efficacy of these modalities in the diagnosis of brain abscess were compared. Results:Hyper-intensity was shown in the lesions of the 9 patients with DWI,the other 2 patients had heterogeneous hypo or hyper-intensity. AA were observed in 10 patients on ' H-MRS, Ac and Suc were observed in 2 patients with positive culture for obligate aerobes. Conclusion: Not all brain abscess lesions showed hyper-intensity on DWI, demonstration of hyper-intensity with reduced ADC is not specific for brain abscess. On 1 H-MRS, AA were specific for the diagnosis of brain abscess, but not all brain abscess leisions showing A A. DWI combined with 1 H-MRS is recommended for the diagnosis and differential diagnosis for patients with suspected brain abscess.