| 红景天多糖对体外正常人T淋巴细胞活性和体外人胃癌细胞增殖的影响(英文) |
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| 引用本文： | 张红旭,韩枫. 红景天多糖对体外正常人T淋巴细胞活性和体外人胃癌细胞增殖的影响(英文)[J]. 中国药物警戒, 2012, 0(9): 573-576 |
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| 作者姓名： | 张红旭 韩枫 |
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| 作者单位： | [1]江苏省徐州市肿瘤医院药剂科,江苏徐州221005 [2]江苏大学附属徐州医院,江苏徐州221005 |
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| 摘 要： | 目的研究红景天多糖对体外正常人T淋巴细胞活性和对体外人胃癌细胞增殖的影响。方法采用MTT比色法和体外细胞培养计数法。结果红景天多糖对体外PHA诱导的正常人外周血T淋巴细胞的增殖有显著性促进作用(P<0.05);红景天多糖对体外人胃癌细胞增殖有显著性抑制作用(P<0.05),且红景天多糖作用强于香菇多糖(P<0.05)。结论红景天多糖可能是一种免疫增强剂,对胃癌可能有一定防治作用。
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| 关 键 词： | 红景天多糖 T淋巴细胞 胃癌 增殖 促进 抑制 |
Effects of Rhodiola Sachalinensis Polysaccharides on Activity of the Human T Lymphocytes in Vitro and Proliferation of the Human Gastric Cancer Cell in Vitro |
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| ZHANG Hong-xu,HAN Feng. Effects of Rhodiola Sachalinensis Polysaccharides on Activity of the Human T Lymphocytes in Vitro and Proliferation of the Human Gastric Cancer Cell in Vitro[J]. Chinese JOurnal of Pharmacovigilance, 2012, 0(9): 573-576 |
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| Authors: | ZHANG Hong-xu HAN Feng |
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| Affiliation: | (Dept of Pharmacy, Xuzhou Cancer Hospital, Jiangsu Xuzhou 221005, China; Affiliated Xuzhou Hospital of Jiangsu University, Jiangsu Xuzhou 221005, China) |
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| Abstract: | Objective To investigate the effects of Rhodiola sachalinensis Polysaccharides（RSP） on activity of the human T lymphocytes in vitro and proliferation of the human gastric cancer cell in vitro. Methods MTT colorimetry assay and in vitro culture cell number count assay were adopted. Results The results show that RSP significantly accelerated the transformation and proliferation of the healthy human peripheral blood T lymphocytes in gitro（P 〈0.05） and inhibited the proliferation of the human gastric cancer cell in gitro（P 〈0.05）, and what＇s more, the inhibitory effect of 1KSP was stronger than that of Lentinan （P 〈0.05）. Conclusion 1KSP may be an immunoenhancer and have some efficacy on the prevention and cure of gastric cancer. |
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| Keywords: | Rhodiola sachalinensis Polysaccharides（RSP） T lymphocytes gastric cancer proliferation acceleration inhibitation |
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