芳香开窍类中药对血脑屏障结构及功能影响的研究进展

目的综述近年来芳香开窍类中药对血脑屏障(BBB)结构及功能的影响,为从中药"芳香开窍"的传统功效中挖掘、筛选、评价和研发创新药物提供文献依据和研究思路。方法对近10年来芳香开窍类中药对血脑屏障结构及功能影响的国内外相关文献进行整理、归纳、分析。结果药理学研究证实芳香开窍类中药主要通过自由透过血脑屏障发挥药效、降低BBB的通透性以保护脑组织以及促进血脑屏障开放三个方面来改变血脑屏障的通透性,另外其作用机制可能与抑制BBB上P-gp的表达和功能有关。结论从P-gp方面加强对芳香开窍类中药作用机制的研究和探索芳香开窍类中药的功效物质基础将是今后研究的重点。

Research Development on the Influence of Traditional Chinese Aromatic Medicine on the Structure and Function of Blood-brain Barrier

Objective The influence of Traditional Chinese Aromatic Medicine on the structure and function of blood-brain barrier, to provide accordance and research ideas for digging, screening, evaluating, developing original new drug from the traditional effect ＂aromatic and resuscitation＂. Methods The related references in recent 10 years both at home and abroad about Traditional Chinese Aromatic Medicine were collated, analyzed and summarized. Results Modem pharmacological studies indicate that the permeability of BBB could be changed by Traditional Chinese Aromatic Medicine in three ways, first it can develop potency by permeating the BBB reinlessly, second it can protect the brain tissue by reducing the permeability of BBB, third it can promote the opening of BBB, while its mechanism of action may be concerned with restraining the expression and function of P-glycoprotein. Conclusion We can lucubrate mechanism of action in traditional Chinese aromatic medicine from P-gp, as well as explore the effective material basis. This will becomg investigate focal point.