胶原复合羟基磷灰石修复下颌骨缺损的组织学观察

在小型猪的下颌骨建立基准骨缺损模型，于缺损区植入胶原复合羟基磷灰石移植材料，用自体骨移植和空白作对照。术后４，８，１２，２４和４８周，分别处死动物取材。光镜下观察动态的组织学变化。结果显示，全部实验动物均存活至观察时间，手术部位无感染及坏死，胶原复合羟基磷灰石移植物与宿生骨融为一体难以分辨。镜下见二者间无纤维组织间隔，成骨活跃，修复过程与自体骨基本一致。未见异物巨细胞及骨坏死所致空泡。认为，胶原复合羟基磷灰石移植材料较自体骨来源广泛，制作方法简便，易于操作，无颗粒游走及移位，对组织无毒、无刺激，不引起机体排斥反应，并可使患者免于因供骨所致的手术创伤，是一种经济、实用及生物相容性好的骨代用品。

HISTOLOGICAL EVALUATION OF COLLAGEN-HYDROXYAPATITE COMPOSITE AS OSSEOUS IMPLANTS IN THE REPAIR OF MANDIBULAR DEFECT

To observe the collagen-hydroxylaptite composite in the repair of bone defect, ten minipigs were chosen to make a mandibular dafect measuring 2 cm in diameter and the composite was implanted, while the use of autogenous bone graft and the blank wese served as control. On the 4, 8, 12, 24 and 48 weeks after the operation, the animals were sacrificed and the samples were examined under light microscope. The result showed that: no infection or necrosis occurred. The composite coalesced with host bone and the outcome was similar to that of the autogenous bone graft. No foreign body giant cells or vacuum left from osteonecrosis was observed. It was suggested that the composite had the advantage of abundant supply, easy to handle and no harm. The biocompatibility was good and might be hopeful as a bone substitute.