bcl—2,P^53在乳腺癌中的表达及其意义

目的：探讨ｂｃｌ－２、Ｐ＾５３在乳腺癌中的表达及其意义。方法：应用免疫组化Ｓ－Ｐ法检测７０例乳腺癌及２０例乳腺良性病变中ｂｃｌ－２和Ｐ＾５３的表达，结果：ｂｃｌ－２与Ｐ＾５３表达之间差异有显著性，呈负相关（Ｐ〈０．０５），ｂｃｌ－２和Ｐ＾５３表达与组织学分级有关（Ｐ〈０．０５），ｂｃｌ－２表达随分级增加阳性率降低，Ｐ＾５３表达与腑窝淋巴转移有关（Ｐ〈０．０５），ｂｃｌ－２表达与腑窝淋巴结转移无关（Ｐ〉０．０５），结论：ｂｃｌ－２表达与淋巴结转移无关，其阳性表达可反映肿瘤属分化好或属早期阶段。Ｐ＾５３表达与淋巴结转移呈正相关。

The expression and significance of bcl-2 and P~(53) of breast cancer

Objective To study the expression and significance of bcl-2 and P53 of breast cancer. Methods Using S-P immunohistochemical method,bcl-2 and P53 expression in 70 cases of breast cancer and 20 cases of benign lesions were detected. Results Inverse correlation was found between the exp-ression of bcl-2 and P53(P<0.05). There was a significant relation between the expression of bcl-2 and P and histological grade(P < 0. 05). bcl-2 was more frequently detected in poorly differentiated carcinomas. The expression of P53 was related to axilla lymph mode metastasis but bcl-2 was not. Conclusion bcl-2 expression it not related to lymph mode metastasis and well differentiation or early stage of tumors may be indicated by bcl-2 positive staining. P53 expression and lymph mode metastasis was positive relation.