| RANTES和糖尿病肾病 |
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| 引用本文： | 王少华,孙子林. RANTES和糖尿病肾病[J]. 现代医学, 2004, 32(2): 129-132 |
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| 作者姓名： | 王少华 孙子林 |
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| 作者单位： | 东南大学附属中大医院,内分泌科,江苏,南京,210009 |
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| 摘 要： | 多种因素可引起糖尿病肾病 (DN)的发生、发展。这些因素可使体内调节正常T细胞表达和分泌的细胞因子 (RANTES)表达和分泌出现改变。RANTES是一种对单核 巨噬细胞有强烈趋化作用的细胞因子 ,它可趋化并激活肾脏中单核巨噬细胞 ,导致细胞外基质大量堆积。因此 ,RANTES在糖尿病肾病的发生、发展中起着重要作用
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| 关 键 词： | 糖尿病 糖尿病肾病 RANTES |
| 文章编号： | 1671-7562(2004)02-0129-04 |
| 修稿时间： | 2003-10-17 |
RANTES and diabetic nephropathy |
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| WANG Shao hua,SUN Zi lin. RANTES and diabetic nephropathy[J]. Modern Medical JOurnal, 2004, 32(2): 129-132 |
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| Authors: | WANG Shao hua SUN Zi lin |
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| Abstract: | Many factors are involved in the development of diabetic nephropathy.Those factors can make change in expression and secretion of regulated upon activation normal T cell expressed and secreted (RANTES).RANTES is a type of cytokines with dramatic mononuclear macrophage chemotaxis,it can attract and activate mononuclear macrophage in kidney,resulting in extra cell matrix (ECM) cumulation in kidney.So RANTES plays key roles in the development of diabetic nephropathy. |
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| Keywords: | diabetes diabetic nephropathy RANTES |
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