PM2.5致过敏、氧化应激、DNA损伤等机制的研究进展

细颗粒物(particulate matter,PM2.5)是城市大气的重要污染物,因其粒径小,面积大,活性强,易附带有毒、有害物质如重金属、微生物等,且在大气中的停留时间长、输送距离远,故而对人体健康具有很大影响。目前已有大量关于其致病机制的研究,如机体免疫功能的改变,诱导细胞氧化应激和损害,基因突变和DNA损伤,但具体的致病机制尚未完全明确,该文就以上致病机制进行综述。

The mechanism of PM2.5 induced allergic,oxidative stress and DNA damage: a review

Particulate matter (PM2.5) is an important element of atmospheric pollutant in city. Because of having the features such as small particle size, large area, strong activity, easy to carry toxic and harmful substances such as heavy metals, microorganisms, and the long stay in the atmosphere and long-conveyed distance, PM2.5 has a great impact on human health. At present, there are a lot of studies on the pathogenic mechanism of PM2.5, such as the change of immune function, the induction of oxidative stress and damage, gene mutation and DNA damage, but the pathogenic mechanism is not yet fully understood. In this paper, we review the pathogenic mechanisms of PM2.5.