食管鳞癌患者血清p53抗体水平与组织分化的关系及术后动态变化

目的 探讨食管鳞癌患者血清p53抗体术前水平与肿瘤组织分化程度的关系及术后动态变化情况.方法 纳入行食管癌根治术的食管鳞癌患者86例为观察组,统计其肿瘤组织分化程度,于术前1d和术后7d、30 d、90 d、180 d检测血清p53抗体水平;纳入同期50例健康体检者为对照组,检测其血清p53抗体水平.结果 观察组血清p53抗体水平及阳性率均高于对照组,差异均具有统计学意义(均P＜0.05).肿瘤分化程度越高,p53抗体水平和阳性率越低(均P＜0.05).观察组血清p53抗体在术后30 d时下降,与术前1d及术后7d比较差异均具有统计学意义(均P＜0.05);术后90 d和180 d时该指标进一步下降,与对照组比较,差异均无统计学意义(均P ＞0.05).结论 检测血清p53抗体有助于判断食管鳞癌分化程度.食管癌根治术可降低血清p53抗体的表达.

Relationship with tissue differentiation and postoperative dynamic change of serum p53 antibody level in patients with esophageal squamous cell carcinoma

Objective To investigate the dynamic changes of serum p53 antibody in patients with esophageal squamous cell carcinoma (ESCC) after surgery,as well as the relationship between preoperative p53 antibody level and the degree of tumor differentiation.Methods Eighty-six cases of esophageal squamous cell carcinoma receiving radical resection were enrolled as the observation group and the degree of tumor differentiation was analyzed.The serum p53 antibody levels were examined one day preoperatively and 7 d,30 d,90 d,180 d postoperatively.Meanwhile,50 healthy subjects were included as the control group and their serum p53 antibody levels were tested accordingly.Results The serum levels of p53 antibody and its positive rates were all significantly higher in the observation group (P ＜ 0.05).Moreover,as the degree of tumor differentiation increased,the p53 antibody levels and its positive rates were decreased (P ＜ 0.05).Furthermore,in the observation group,the level of serum p53 antibody was significantly decreased at 30 d after operation,compared with those at 1 d before operation or 7 d after operation (P ＜ 0.05).The levels of p53 antibody were further decreased at 90 d and 180 d after operation,and became comparable with the control group (P ＞ 0.05).Conclusion Serum p53 antibody test can help to determine the degree of tumor differentiation of ESCC.Radical resection of esophageal cancer can inhibit the expression of p53 antibody in serum.