| 肾脏肾素-血管紧张素系统与胎源性肾小球硬化 |
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| 引用本文： | 万阳,敖英,汪晖. 肾脏肾素-血管紧张素系统与胎源性肾小球硬化[J]. 生殖与避孕, 2017, 0(5): 429-432. DOI: 10.3760/cma.j.issn.2096-2916.2017.05.018 |
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| 作者姓名： | 万阳 敖英 汪晖 |
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| 作者单位： | 1. 430071,武汉大学基础医学院药理学系;2. 430071 武汉大学基础医学院药理学系;430071武汉,发育源性疾病湖北省重点实验室 |
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| 基金项目： | 国家自然科学基金项目(81430089 |
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| 摘 要： | 肾脏肾素-血管紧张素系统(renin-angiotensin system,RAS)在肾小球硬化的发生发展中起到重要作用。近年来的研究表明,胚胎肾脏发育不良能够增加成年后肾脏疾病的易感性,且证实肾小球硬化可能具有宫内发育起源。相关研究也表明,各种因素导致的孕期不良宫内环境会分别导致胚胎期、成年后RAS出现病理性改变,进而导致胎儿肾脏发育不良、致成年后肾小球硬化易感。
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| 关 键 词： | 肾脏肾素-血管紧张素系统(RAS) 胎源性肾小球硬化 孕期不良环境 |
Renin-angiotensin system of kidney and fetal originated glomerulosclerosis |
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| Wan Yang,Ao Ying,Wang Hui. Renin-angiotensin system of kidney and fetal originated glomerulosclerosis[J]. Reproduction and Contraception, 2017, 0(5): 429-432. DOI: 10.3760/cma.j.issn.2096-2916.2017.05.018 |
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| Authors: | Wan Yang Ao Ying Wang Hui |
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| Abstract: | It is well known that renin-angiotensin system of kidney (RAS) plays a crucial role in the development of glomerulosclerosis.Many previous studies have suggested that fetal renal dysplasia might increase susceptibility to renal diseases in adult offspring,which indicates that glomerulosclerosis has the fetal origin.Related studies have shown that adverse prenatal environment resulting from various factors can lead to pathological changes of RAS in fetal and adult period respectively,leading to dysplasia of fetal kidney development and the susceptibility to glomerulosclerosis in the adult offspring. |
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| Keywords: | Renin-angiotensin system (RAS) of kidney Fetal originated glomerulosclerosis Adverse prenatal environment |
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