使用促性腺激素释放激素激动剂过程中妊娠的临床分析

目的 研究在控制性超促排卵(COH)使用促性腺激素释放激素激动剂(GnRH-a)过程中妊娠的临床结局。方法 回顾性分析我中心4 988例体外受精或卵母细胞质内单精子显微注射受精与胚胎移植(IVF/ICSI-ET)长方案超促排卵使用GnRH-a过程中妊娠的21例临床资料。结果 在使用GnRH-a过程中21例妊娠,妊娠发生率为0.42%(21/4 988)。其中宫内孕19例,2例足月分娩健康新生儿;8例妊娠中;7例自然流产,自然流产发生率为33.33%(7/21);2例异位妊娠,异位妊娠发生率为9.52%(2/21);2例失访。结论 在COH中使用GnRH-a可导致意外妊娠,GnRH-a对妊娠结果无不良影响、无胎儿致畸作用,且有良好的妊娠结局。

Analysis of pregnancies exposed to gonadotropin-releasing hormone agonist during controlled ovarian hyperstimulations

Objective To evaluate the outcomes of human gestations exposed in very early stage to gonadotropin-releasing hormone agonist (GnRH-a) during controlled ovarian hyperstimulation (COH).Methods The clinical data including the pregnancy outcomes of 21 cases were retrospectively analyzed,who were exposed to GnRH-a at very early stage of their pregnancies,among 4 988 in vitro fertilization or intracytoplasma sperm injection and embryo transfer (IVF/ICSI-ET) cycles.Results Twenty-one cases of pregnancies were found during their COH,the incidence was 0.42％.Among 21 cases,19 were intrauterine gestation,2 produced 2 normal babies,8 were carrying on and 7 pregnancies were aborted,2 were ectopic pregnancies with a rate of 9.52％ (2/21),and 2 pregnancies lost following up.Conclusion There appear to be no increased risk of birth defects or pregnancy wastage in pregnancies exposed to daily low-dose GnRH-a therapy in early of gestation.