宫颈管内与宫腔内供精人工授精妊娠结局的比较

目的比较分析宫颈管内和宫腔内供精人工授精(AID)妊娠结局的影响。方法对548个AID治疗周期进行回顾性分析,其中宫颈管内人工授精(ICI)200例360个周期,宫腔内人工授精(IUI)125例188个周期,对2种授精部位的AID妊娠结局进行比较。结果 ICI组的周期妊娠率为14.74%(51/346),其中自然周期妊娠率为18.54%(33/178),促排卵周期妊娠率为10.71%(18/168),流产率为11.76%(6/51);IUI组的周期妊娠率为28.49%(51/179),其中自然周期的妊娠率为32.04%(33/103),促排卵周期妊娠率为23.68%(18/76),流产率为5.88%(3/51);组间差异均有统计学意义(P0.05)。结论授精部位可能是影响AID成功妊娠的关键因素之一,采用IUI法可能会提高AID的妊娠率。

Comparison of pregnancy results between intrauterine insemination and intracervical insemination

Objective To compare the difference of outcomes between intrauterine insemination (IUI) and intracervical insemination (ICI) with donor's semen.Methods In this retrospective study,325 patients were treated with 548 cycles artificial insemination with donor semen (AID) during the period from January 2015 to August 2016 in assisted reproductive technology research unit of Fujian maternity and children health hospital of Fujian medical university.Totally 200 cases including 360 cycles of ICI,and 125 cases including 188 cycles of IUI were performed and their pregnancy outcome were compared respectively.Results The total pregnancy rates,the pregnancy rates of natural treatment cycle,the pregnancy rates of ovarian stimulation treatment cycle and miscarriage rates in ICI groups were 14.74％,18.54％,10.71％,11.76％ and in IUI groups were 28.49％,32.04％,23.68％,5.88％,respectively.The comparative difference between the two groups was significant (P＜0.05).Conclusion Insemination parts may be one of the key factors influencing the AID successful pregnancy,IUI may improve the pregnancy outcome of AID.