输血相关性铁过载在血液肿瘤中的研究进展

输血相关性铁过载破坏机体铁稳态，从而损害重要脏器结构，导致重要脏器的功能障碍。铁过载影响患者预后，促进骨髓增生异常综合征（ Myelodysplastic syndrome ，MDS）向急性白血病转化，降低造血干细胞移植后患者总生存率，增加造血干细胞移植后治疗相关死亡率，并增加感染的机会。祛铁治疗可延缓骨髓增生异常综合征向急性白血病的进展，延长移植后患者的总生存期，并表现出一定的抗增殖活性。

The research progress in transfusion-related iron overload in hematological malignancies

Transfusion -related iron overload damage iron homeostasis of organism ,which damages the structure of the vital organs and leads to the dysfunction of important organs .Iron overload affects the prognosis of the patients,which promotes myelodysplastic syndrome transformation to acute leukemia and reduces the total sur -vival rate of patients with hematopoietic stem cell transplantation ,which increases the treatment related mortality after hematopoietic stem cell transplantation and increases the chance of infection .Iron depletion therapy can de-lay the progression of acute leukemia and prolong the survival time of the patients with acute leukemia and show a certain anti-proliferative activity .