| 乳腺癌肝转移机制研究进展 |
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| 引用本文： | 李博(综述),陈雪松(审校). 乳腺癌肝转移机制研究进展[J]. 实用肿瘤学杂志, 2017, 0(1): 48-52. DOI: 10.11904/j.issn.1002-3070.2017.01.010 |
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| 作者姓名： | 李博(综述) 陈雪松(审校) |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院乳腺内科 哈尔滨 150081 |
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| 基金项目： | 国家自然科学基金(81573001)；黑龙江省科技厅项目(LC201438) |
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| 摘 要： | 肝脏是乳腺癌常见的转移部位。乳腺癌肝转移的过程包括多个步骤，涉及乳腺癌细胞和肝脏微环境中的多种因素。在本文中，我们综述了与乳腺癌肝转移相关的分子（包括连接蛋白类、蛋白激酶类、miRNAs）、信号转导通路（包括CXCL12－CXCR4轴、Wnt／β－catenin信号通路、AF1q／TCF7／CD44调节轴、层黏连蛋白受体／Akt／ERK信号通路、瘦素／ERK／IL－8信号通路）以及肝脏微环境中的影响因素（包括缺氧诱导因子、肿瘤相关成纤维细胞、脂肪基质干细胞、金属蛋白酶、选择性配体、炎性细胞免疫浸润）。
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| 关 键 词： | 乳腺癌 肝转移 微环境 |
Mechanisms involved in liver metastasis of breast cancer |
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| LI Bo,CHEN Xuesong. Mechanisms involved in liver metastasis of breast cancer[J]. Journal of Practical Oncology, 2017, 0(1): 48-52. DOI: 10.11904/j.issn.1002-3070.2017.01.010 |
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| Authors: | LI Bo CHEN Xuesong |
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| Abstract: | Liver is the common metastatic site of breast cancer .The process of liver metastasis consists of multiple steps and involves various factors from breast cancer cells and the liver micro -environment .In this re-view,we reviewed the molecular(including the connection of proteins ,protein kinases,miRNAs),signal transduc-tion pathways(including CXCL12-CXCR4 axis,Wnt/beta-catenin signaling pathway,AF1q/TCF7/CD44 regu-latory axis,laminin receptor/Akt/ERK signaling pathway,leptin/ERK/IL-8 signaling pathway)and the influen-cing factors(including hypoxia inducible factors,tumor-associated fibroblasts,adipose tissue matrix stem cells, metalloproteinases,selective ligands,inflammatory cell infiltration)associated with the liver micro -environment in breast cancer . |
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| Keywords: | Breast cancer Liver metastasis Micro-environment |
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