头颈部肿瘤术后放疗后淋巴水肿发生的影响因素

目的 探讨头颈部肿瘤患者术后放疗后淋巴水肿发生的影响因素.方法 收集接受术后放疗的128例头颈部肿瘤患者,随访1年~2年7个月.回顾性分析年龄、性别、颈部淋巴结清扫术、放疗剂量、同步化疗、放射性皮炎以及预防性使用改善微循环药物与放疗后淋巴水肿的关系.结果 颈部淋巴结清扫术、放疗剂量和预防性使用改善微循环药物是影响淋巴水肿发生的重要因素(均P<0.05).结论 接受颈部淋巴结清扫术以及术后放疗剂量60 Gy的头颈部肿瘤患者发生局部淋巴水肿的风险较高,而预防性使用改善微循环药物可以有效预防水肿的发生.

Risk factors of lymphoedema following postoperative radiation for head and neck tumors

Objective To analyze the risk factors of lymphoedema following postoperative radiation in patients with head and neck tumors.Methods One-hundred-and-twenty-eight patients with head and neck tumors undergoing postoper-ative radiation were enrolled,and followed up for 12 to 31 months.The association of factors,including age,gender,neck lymph node dissection,radiotherapy dose,synchronous chemotherapy,radioactive dermatitis and the preventive usage of mi-crocirculation drugs,with the development of lymphoedema after radiotherapy were analyzed.Results Neck lymph node dissection,radiotherapy dose,and the not using microcirculation drugs were independent risk factors of lymphoedema (all P <0.05).Conclusions Head and neck tumor patients who have received neck lymph node dissection and /or postopera-tive radiation therapy with a dosage of 60 Gy have higher risk of developing lymphoedema.Preventive usage of microcircula-tion drugs can effectively prevent the occurrence of lymphoedema.