39例早期先天性梅毒的临床分析

目的了解先天性梅毒的流行病学特点、临床特征及其治疗预后情况,为先天性梅毒的防治提供参考。方法对2010—2014年住院治疗的先天性梅毒患儿的病历资料进行回顾性分析。结果①共39例资料完整的先天性梅毒患儿入选;②患儿母亲正规驱梅治疗5例、非正规驱梅治疗34例;③临床和体征主要表现为皮肤黏膜损害、肝损伤、血液系统损害、骨损害、心脏损害、中枢神经系统损害、发热、脾大;④患儿均予以青霉素治疗,未见青霉素不良反应;⑤症状体征消失的有11例、症状体征好转17例、无改善3例。结论先天性梅毒中以早期先天性梅毒最常见;早期先天性梅毒可以有皮肤黏膜、肝脏、血液系统、骨骼系统、中枢神经系统及心脏损害等多器官损害;青霉素是先天性梅毒治疗的首选药物,但早期先天性梅毒的预后值得关注。

Clinical analysis on 39 cases of congenital syphilis

Objective To investigate the epidemiological characteristics, clinical features and prognosis of congenital syphilis, so as to provide reference for the prevention and treatment of congenital syphilis. Methods A retrospective analysis was carried out based on the medical records of children with congenital syphilis in the First Affiliated Hospital of Anhui Medical University from 2010 to 2014. Results A total of 39 patients with complete data of congenital syphilis were selected. For the treatment of the children's mothers, regular treatment was given in 5 cases, and irregular treatment in the other 34 cases. Clinical signs and symptoms mainly presented as damages of mucocutaneous, liver, blood system, bone, heart, central nervous system, as well as fever and splenomegaly. All the patients were treated with penicillin, and no adverse reactions were found. For the prognosis, symptoms and signs disappeared in 11 cases, improved in 17 cases and no obvious improvement in 3 cases. Conclusion In congenital syphilis, early congenital syphilis is most common, which maybe presents a variety damages of skin and mucous membrane, liver, blood system, bone, central nervous system and heart; Penicillin is the preferred drug treatment of congenital syphilis; the prognosis of early congenital syphilis is worthy of paying attention to.