输精管结扎与迟发性性腺功能减退症的关系

目的评价输精管结扎对≥40岁男性老年男性症状量表(the aging males’symptoms scale,AMS)评分的影响。方法采用分层整群抽样的方法随机抽取≥40岁男性为调查对象,结合问卷调查以及体格检查的结果,分析输精管结扎对健康相关生活质量和症状(AMS)评分的影响。结果输精管结扎组AMS评分(38.7±10.8)及迟发性性腺功能减退症(LOH)症状阳性率(90.8%)均高于非结扎组(31.3±10.0,64.0%),差异有统计学意义(P0.05);校正混杂因素后,结扎组与非结扎组之间的躯体症状(β=2.325,95%CI=1.29~3.36)、心理症状(β=0.805,95%CI=0.09~1.52)、性功能症状(β=2.693,95%CI=1.97~3.42)及AMS总评分(β=5.809,95%CI=3.86~7.76)的差异均有统计学意义(P0.05);结扎10年组的性功能症状评分(12.1±4.9)高于同年龄的对照(9.5±3.7)(P0.05);结扎20年组的躯体症状评分(15.2±5.5)、性功能症状评分(13.8±3.9)以及AMS总评分(37.6±9.9)高于同年龄的对照(13.2±4.8,10.8±4.1,31.7±9.9)(P0.05);结扎30年组的躯体症状评分(16.8±6.3)、心理症状评分(8.9±4.1)、性功能症状评分(14.6±3.5)以及AMS总评分(40.3±11.0)亦高于同年龄的对照(13.5±4.8,7.7±3.3,11.1±4.2,32.3±10.0)(P0.05)。结论输精管结扎可能会导致AMS评分升高,且在输精管结扎年限长的人群中尤其明显。

Relationship of vasectomy with late-onset hypogonadism

Objective To investigate the impact of vasectomy on the aging males' symptoms (AMS) score.Methods Participants aged ≥40 years were randomly sampled by stratified-cluster method.A questionnaire and a physical examination were taken for each one,and combining both results to analyze the impact of vasectomy on AMS score.Results The positive rate of AMS symptom and the AMS score in the ligation group (38.7± 10.8) was higher than the non-ligation group (31.3± 10.0) (P＜0.05).After adjusted by possible confounding factors,the statistically significant (P＜0.05) difference was found in somatic symptoms (β=2.235,95％ CI=1.29-3.36),psychological symptoms (β=0.805,95％ CI=0.09-1.52),sexual functional symptoms (β=2.693,95％ CI=1.97-3.42) and total score of AMS (β=5.809,95％ CI=3.86-7.76),all grouped by ligation.The score of sexual function in the 10-year ligation group was higher than control group with the same age (P＜0.05).The scores of somatic symptoms,sexual symptom and AMS were higher than control group with the same age (P＜0.05).The scores of somatic symptoms (15.2 ± 5.5,16.8 ± 6.3),sexual symptom (13.8 ± 3.9,14.6 ± 3.5) and AMS (37.6 ± 9.9,40.3 ± 11.0) in the 20-year and 30-year ligation group were higher than control group (13.2 ± 4.8,13.5 ± 4.8),(10.8±4.1,11.1 ± 4.2),(31.7 ± 9.9,32.3 ± 10.0) with the same age (P＜0.05).The scores of psychological symptoms (8.9 ± 4.1) was higher in the 30-year group than control group (7.7 ± 3.3) with the same age (P＜0.05).The scores of somatic symptoms,psychological symptoms,sexual function and AMS were higher in the 30-year group than control group with the same age (P＜0.05).Conclusion The vasectomy may increase AMS score,especially distinct in the participants with long-term vasectomy.