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| 神经核蛋白γ（γ-syn）在直肠癌组织中表达的研究 | |
| 引用本文： | 江滨,张红英,谭妍妍,陈艳妮,徐斐,丁义江.神经核蛋白γ（γ-syn）在直肠癌组织中表达的研究[J].结直肠肛门外科,2010,16(2):75-78. |
| 作者姓名： | 江滨 张红英 谭妍妍 陈艳妮 徐斐 丁义江 |
| 作者单位： | 1. 南京中医药大学,江苏南京,210000 2. 南京中医药大学第三附属医院病理科 3. 南京中医药大学第三附属医院全国肛肠治疗中心 4. 南京市疾病控制中心 |
| 摘 要： | 目的研究直肠癌组织中γ-syn蛋白的表达情况。方法免疫组织化学法检测86例直肠癌组织γ-syn蛋白的表达。同时收集临床资料，包括年龄、性别、肿瘤距肛门距离、术前血清CEA水平、肿瘤分化程度、有无淋巴结转移。结果86例直肠癌组织中都有γ-syn蛋白的表达（86／86）。γ-syn蛋白的表达与患者性别、年龄、肿瘤距肛门距离、术前血清CEA水平之间无相关性；与直肠癌的组织分化程度、有无淋巴结转移无关。绪论直肠癌组织高表达γ-syn蛋白；γ-syn蛋白是直肠癌普遍存在表达的蛋白，可以作为直肠癌的生物标记。 |
| 关 键 词： | 神经核蛋白γ 直肠癌 表达 |
The expression of synuclein-gamma in rectal adenocarcinoma |
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| Institution: | Bin Jiang , Hongying Zhang , Yanyan Tan , et al( 1. Nanjing University of Traditional Chinese Medicine, Nanjing 210000, China. 2. Department of Pathology, Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210000, China. 3. National Center of Colorectal Disease of Traditional Chinese Medicine, Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210000 ,China.) |
| Abstract: | Objective To investigate the immunohistochemical expression of synuclein-gamma{ γ-syn） in rectal adenocarcinoma and its correlation with rectal carcinomas. Methods Immunohistochemistry with anti- γ-syn antibody was performed in rectal adenocarcinoma tissues （ n =86）. Results γ-syn expression was detected in all of adenocarcinoma tissue {86/86}. γ-syn expression was not related with gender, age, CEA level in serum before operation, differentiation, distance from the anal verge to tumor and metastasis of lymph nodes. Conclusion γ-syn is highly expressed in rectal adenocarcinoma, γ-syn is a ubiquity express protein in rectal adenocarcinoma and it may served as a marker of rectal adenocarcinoma. |
| Keywords: | Synuclein-gamma { γ-syn} Rectal adenocarcinomas Expression |
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