| 吉非替尼联合胸腔内化疗治疗伴有恶性胸水的非小细胞肺癌的临床研究 |
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| 引用本文： | 潘德键,周锡建,王东林. 吉非替尼联合胸腔内化疗治疗伴有恶性胸水的非小细胞肺癌的临床研究[J]. 现代肿瘤医学, 2010, 18(3) |
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| 作者姓名： | 潘德键 周锡建 王东林 |
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| 作者单位： | 1. 江苏大学临床医学院解放军第101医院血液肿瘤科,江苏,无锡,214044
2. 同济大学附属同济医院肿瘤科,上海,200065 |
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| 基金项目： | 江苏大学临床医学科技发展基金资助项目 |
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| 摘 要： | 目的:探讨吉非替尼联合胸腔内化疗治疗伴有恶性胸水的非小细胞肺癌的疗效和安全性.方法:26例伴有中、大量恶性胸水的晚期非小细胞肺癌患者,采用胸腔置管引流尽量放干胸水后,胸腔内注射化疗药物顺铂(DDP)40mg/m2、香菇多糖2mg、地塞米松10mg,从胸腔内化疗后的第3天口服吉非替尼250mg/d,直到病变进展或其他原因停药.每3个月对病灶进行1次CT检查.结果:第3个月CT复查结果显示:全组胸水控制有效率为69.2%(18/26),肿瘤病灶治疗有效率为34.6%(9/26),疾病控制率73.1%(19/26),临床受益反应为88.5%(23/26).中位疾病进展时间(TTP)为8.2个月(95%可信区间:1.8-14.2月),中位生存期(MST)为12.4个月(95%可信区间:3.1-37.4月),1年生存率为46.2%(12/26).主要不良反应是Ⅰ、Ⅱ度皮肤毒性.结论:吉非替尼联合胸腔内化疗治疗伴有恶性胸水的非小细胞肺癌具有较好的疗效和安全性.
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| 关 键 词： | 吉非替尼 化疗 胸腔积液 非小细胞肺癌 |
Efficacy and safety of gefitinib combined with intrathoracic chemotherapy in advanced non-small cell lung cancer patients with pleural effusion |
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| PAN De-jian,ZHOU Xi-jian,WANG Dong-lin. Efficacy and safety of gefitinib combined with intrathoracic chemotherapy in advanced non-small cell lung cancer patients with pleural effusion[J]. Journal of Modern Oncology, 2010, 18(3) |
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| Authors: | PAN De-jian ZHOU Xi-jian WANG Dong-lin |
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| Affiliation: | PAN De-jian 1,ZHOU Xi-jian 1,WANG Dong-lin 2 1Department of Oncology,101st Hospital of PLA,Clinical Medical College of Jiangsu University,Jiangsu 214044,China,2Department of Oncology,Affiliated Tongji Hospital,Tongji University,Shanghai 200065 |
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| Abstract: | Objective:To evaluate the efficacy and safety of gefitinib combined with intrathoracic chemotherapy in advanced non-small cell lung cancer patients with pleural effusion.Methods:Twenty six patients with advanced NSCLC and medium or abundant pleural effusion were selected.Pleural effusion was emptied with thoracentesis.The intrathoracic chemotherapy:cisplatin (DDP) 40mg/m 2,lentinan 2mg,dexamethasonen 10mg.All patients received gefitinib of 250mg/d after 3 days from intrathoracic chemotherapy until disease p... |
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| Keywords: | gefitinib chemotherapy pleural effusion non-small cell lung cancer |
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