| 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价 |
| |
| 引用本文： | 张中湖,李皓,李军,陆峰.药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J].药学实践杂志,2015,33(5):441-444. |
| |
| 作者姓名： | 张中湖 李皓 李军 陆峰 |
| |
| 作者单位： | 山东省食品药品检验研究院, 山东 济南 250101,第二军医大学药学院, 上海 200433,山东省食品药品检验研究院, 山东 济南 250101,第二军医大学药学院, 上海 200433 |
| |
| 基金项目： | 科技部重大科学仪器设备开发专项(2012YQ180132) |
| |
| 摘 要： | 目的 建立常用药物辅料(甘油)中有毒掺杂物(二甘醇)的快速检测方法。 方法 利用拉曼/近红外光谱法结合移动窗口相关系数法评价有毒掺杂物的检测灵敏度。 结果 拉曼光谱下获得的检测灵敏度优于近红外光谱,同时移动窗口法可进一步提高检测灵敏度。 结论 拉曼光谱法有望成为现场快速检测药物辅料中掺杂有毒物质的有效方法。
|
| 关 键 词： | 药物辅料 拉曼光谱法 近红外光谱法 灵敏度 移动窗口 |
| 收稿时间： | 2015/5/29 0:00:00 |
| 修稿时间： | 2015/7/26 0:00:00 |
The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient |
| |
| ZHANG Zhonghu,LI Hao,LI Jun and LU Feng.The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J].The Journal of Pharmaceutical Practice,2015,33(5):441-444. |
| |
| Authors: | ZHANG Zhonghu LI Hao LI Jun and LU Feng |
| |
| Institution: | Shandong Institute for Food and Drug Control, Jinan 250101, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Shandong Institute for Food and Drug Control, Jinan 250101, China and School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
| |
| Abstract: | Objective To develop a rapid method for the detection of toxic adulterant (diethylene glycol) in pharmaceutical excipient (glycerol). Method The detection sensitivity of Raman/ near infrared (NIR) spectroscopy combined with moving window correlation coefficient (MWCC) method was evaluated. Results The detection sensitivity of Raman spectroscopy was superior to that of NIR spectroscopy and with the assistance of MWCC method; the sensitivity had been further improved. Conclusion Raman spectroscopy has the potential to become the effective method in the on-site detection of toxic adulterant in pharmaceutical excipient. |
| |
| Keywords: | pharmaceutical excipient Raman spectroscopy near infrared (NIR) spectroscopy sensitivity moving window correlation coefficient (MWCC) method |
|
| 点击此处可从《药学实践杂志》浏览原始摘要信息 |
| 点击此处可从《药学实践杂志》下载免费的PDF全文 |
