| 丹参素及其衍生物心血管作用机制的研究进展 |
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| 引用本文： | 焦育强,刘文斌,袁夏,姜玉,田霖,金磊,张川. 丹参素及其衍生物心血管作用机制的研究进展[J]. 药学实践杂志, 2015, 33(5): 389-391,405 |
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| 作者姓名： | 焦育强 刘文斌 袁夏 姜玉 田霖 金磊 张川 |
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| 作者单位： | 福建中医药大学药学院, 福建 福州 350108,第二军医大学药学院, 上海 200433,第二军医大学药学院, 上海 200433,第二军医大学药学院, 上海 200433,福建中医药大学药学院, 福建 福州 350108,第二军医大学药学院, 上海 200433,第二军医大学药学院, 上海 200433 |
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| 摘 要： | 丹参素是丹参的主要水溶性活性成分之一,具有多种药理活性,尤其对心血管系统具有明显的保护作用。笔者从抗凋亡、抗氧化、抑制钙超载和作用于炎症反应通路等方面,对丹参素及其衍生物心血管药理作用机制进行综述。
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| 关 键 词： | 丹参素 丹参素衍生物 抗凋亡 抗氧化 钙超载 炎症反应 |
| 收稿时间： | 2013-12-23 |
| 修稿时间： | 2014-04-18 |
Study progress of Danshensu and its derivatives in cardiovascular mechanism |
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| JIAO Yuqiang,LIU Wenbin,YUAN Xi,JIANG Yu,TIAN Lin,JIN Lei and ZHANG Chuan. Study progress of Danshensu and its derivatives in cardiovascular mechanism[J]. The Journal of Pharmaceutical Practice, 2015, 33(5): 389-391,405 |
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| Authors: | JIAO Yuqiang LIU Wenbin YUAN Xi JIANG Yu TIAN Lin JIN Lei ZHANG Chuan |
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| Affiliation: | School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China,School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China and School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Danshensu is one of the main water soluble active ingredients of Salvia miltiorrhiza, which has many pharmacological activities, especially in cardiovascular system. The cardiovascular pharmacological mechanism of Danshensu and its derivatives from the view of anti-apoptosis, antioxidant, inhibiting calcium overload and role in the inflammatory reaction pathways etc. were summarized in this article. |
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| Keywords: | Danshensu derivatives anti-apoptosis antioxidant calcium overload inflammatory reaction |
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