心房颤动患者的64层螺旋CT冠状动脉成像的初步临床研究

目的 探讨64层螺旋CT在心房颤动患者冠状动脉CT血管成像(CTA)中的应用价值.方法 分析31例心房颤动患者的冠状动脉CTA图像质量,利用血管分析软件判断血管有无狭窄并测量狭窄率,其中10例患者的冠状动脉CTA结果与冠状动脉造影(CAG)结果进行了对照分析.对于不同心率患者图像质量的比较分析采用多个独立样本(等级资料)的非参数秩和榆验.结果所有患者均采用绝对值时间法重组心脏容积数据.对31例患者中364段血管节段进行成像质量分析:心率为47～69次/min组图像质量为优、良、中和差的血管节段数分别为85、41、5和8个,心率为70～79次/min组分别为63、16、13和15个,心率为80～105次/min组分别为46、25、23和24个,3组间成像质量差异有统计学意义(H=22.08,P＜0.01).10例与CAG进行对照,共分析冠状动脉血管125段,CTA诊断血管狭窄程度≥50%的敏感度为85.0%(17/20),特异度为95.2%(100/105),阳性预测值为77.3%(17/22),阴性预测价值为97.1%(100/103).冠状动脉CTA低估了3段血管的病变,过度评价了5段血管.结论64层螺旋CT对心房颤动患者进行冠状动脉CTA检查具有一定的临床价值.

Coronary artery imaging with 64-slice spiral CT in atrial fibrillation patients:initial experience

Objective To discuss the clinical value of coronary artery imaging using 64-slice spiral CT in patient with atrial fibrillation.Methods The images of 31 patients with atrial fibrillation who underwent contrast-enhanced CT coronary angiography were evaluated.The presence of stenosis on each segment of coronary arteries was recorded and their degree of stenosis was measured using the vessel analysis software.Ten patients additionally underwent conventional coronary angiography.The results of conventional coronary angiography were compared with CT coronary angiography of the 10 patients.Results Image reconstruction was based on absolute timing.The image quality of 364 coronary vessel segments on the images from 31 patients was evaluated and defined as excellent,fine,moderate or poor.The image quality was excellent,fine,moderate and poor in 85,41,5,and 8 vessel segments respectively in patient group with heart rate between 47 beat per minent(bpm)and 69 bpm;and in 63,16,13,and 15 vessel segments respectively in patent group with heart rate between 70 bpm and 79 bpm;and in 46,25,23,and 24 vessel segments in patient group with heart rate between 80 bpm and 105 bpm.There was significant difference among the three patient groups(H=22.08,P＜0.01).Comparison was carried out between CT angiographic findings and conventional angiographic findings of the 125 segments of the coronary arteries in the 10 patients who underwent conventional coronary angiography.The sensitivity and specificity of CT angiography for diagnosing vessel with significant coronary stenosis(≥50% narrowing)was 85.0%(17/20)and 95.2%(100/105),respectively.Positive predictive value was 77.3%(17/22),and negative predictive value was 97.1%(100/103).Coronary CTA underestimated the lesions of 3 vessel segments and overestimated the lesions of 5 vessel segments.Conclusion Coronary artery imaging with 64-slice row CT had clinical value for patients with atrial fibrillation.